Molecular Basis of Inheritance — Concept Maps
ICSE · Class 12 · Biology
4 concept maps of Molecular Basis of Inheritance for ICSE Class 12 Biology, each also written out as a text outline.
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DNA as Genetic Material — Key Experiments
The map in words
- Proving DNA is Genetic Material
- Griffith 1928
- S strain smooth + R strain rough
- Heat-killed S + live R = Virulent
- Transforming principle exists
- Avery MacLeod McCarty 1944
- DNase destroyed transformation
- RNase and protease did NOT
- CONCLUSION: DNA is transforming principle
- Hershey Chase 1952
- 35S labels protein coat
- 32P labels DNA
- 32P found in bacteria after infection
- CONCLUSION: DNA is genetic material
- Griffith 1928
Meselson-Stahl Experiment
The map in words
- E. coli grown on 15N heavy medium
- All DNA is 15N heavy
- Transfer to 14N normal medium
- After 1st generation
- D1
- After 2nd generation
- 50% 15N-14N hybrid
- 50% 14N-14N light
- PROVES: Semiconservative Replication
- After 2nd generation
- D1
- After 1st generation
- Transfer to 14N normal medium
- All DNA is 15N heavy
- Intermediate
DNA Structure Key Numbers
The map in words
- DNA Double Helix - B form
- 3.4 Angstrom per base pair
- 10 base pairs per turn
- 34 Angstrom per complete turn
- 20 Angstrom diameter
- Base Pairing Rules
- A = T two hydrogen bonds
- G equivalent C three hydrogen bonds
- Anti-parallel strands
- One strand 5 to 3
- Other strand 3 to 5
How genetic information is stored, copied, expressed, regulated, and analyzed in living organisms
The map in words
- How genetic information is stored, copied, expressed, regulated, and analyzed in living organisms
- Gene
- Nucleic acids
- DNA structure
- Chargaff's rules
- RNA structure
- Search for genetic material
- DNA replication
- Central dogma
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