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Molecular Basis of Inheritance

ICSE · Class 12 · Biology

Complete topic list for Molecular Basis of Inheritance in ICSE Class 12 Biology. Key concepts, sub-topics, and what to focus on for board exams.

60 questions36 flashcards

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A flowchart illustrating the sequential steps involved in DNA fingerprinting (DNA profiling), from DNA isolation to the detection of hybridized DNA fragments, including restriction digestion, gel elec
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4 Topics · ICSE Class 12 Biology

Topics in Molecular Basis of Inheritance

1

  • Griffith 1928: Transformation — heat-killed virulent S strain transformed R strain; "transforming principle"
  • Avery, MacLeod, McCarty 1944: DNase destroyed transformation → DNA is transforming principle
  • Hershey & Chase 1952: T2 phage experiment; 35S (protein coat) stayed outside; 32P (DNA) entered bacteria → DNA is genetic material
2

  • Anti-parallel double helix
  • Base pairs: A=T (2 hydrogen bonds); G≡C (3 hydrogen bonds)
  • Chargaff's rules: A=T, G=C (in double-stranded DNA)
3

  • Nucleosome: ~200 bp DNA wrapped around histone octamer
  • Histone octamer: H2A + H2B + H3 + H4 (2 of each = 8 histones)
  • H1: linker histone — NOT part of octamer; stabilises 30 nm chromatin fibre
4

  • Proved SEMICONSERVATIVE replication using 15N/14N E. coli
  • After 1 generation: ALL hybrid (15N/14N) — intermediate density
  • After 2 generations: 50% hybrid + 50% light (14N/14N)

Chapter Syllabus

Molecular Basis of Inheritance is part of the ICSE Class 12 Biology syllabus. It covers the core concepts and topics prescribed by the board for the 2026 academic year.

Frequently Asked Questions

What are the important topics in Molecular Basis of Inheritance for ICSE Class 12 Biology?
Key topics in Molecular Basis of Inheritance include DNA as Genetic Material — Key Experiments, Meselson-Stahl Experiment, DNA Structure Key Numbers. These are the concepts ICSE Class 12 examiners draw on most — study them first, then practise related questions.
How to score full marks in Molecular Basis of Inheritance — ICSE Class 12 Biology?
Understand the core concepts first, then work through the 60 practice questions available for this chapter. Revise formulas and definitions regularly, and use flashcards for quick recall before the exam.

Sources & Official References

Content is aligned to the official syllabus. Refer to the board website for the latest curriculum.

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