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Chapter 5 of 13
Syllabus

Molecular Basis of Inheritance — Syllabus

Madhya Pradesh Board · Class 12 · Biology

What Molecular Basis of Inheritance covers in Madhya Pradesh Board Class 12 Biology: 4 topics, for the 2026-27 session.

44 questions88 flashcards3 formulas & key relations5 concepts

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A labeled diagram illustrating the Watson and Crick model of DNA, showing the double helical structure, antiparallel strands, sugar-phosphate backbone, nitrogenous base pairing (A-T, G-C) with hydroge
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4 Topics · Madhya Pradesh Board Class 12 Biology · 2026-27

Topics in Molecular Basis of Inheritance

1

1. DNA: Structure and Packaging

  • DNA is a long polymer of deoxyribonucleotides.
  • A nucleotide has three parts: a nitrogenous base, a pentose sugar, and a phosphate group.
  • Purines are adenine and guanine.
2

2. Search for the Genetic Material

  • DNA was first identified as an acidic nuclear substance by Friedrich Meischer in 1869 and named Nuclein.
  • Frederick Griffith worked with Streptococcus pneumoniae S and R strains in 1928.
  • S strain is virulent and R strain is non-virulent.
3

3. DNA versus RNA and RNA World

  • DNA is more stable than RNA because it lacks the 2' OH group and contains thymine.
  • RNA has an extra 2' OH group, making it more reactive and less stable.
  • RNA acts as genetic material in some viruses such as TMV and QB bacteriophage.
4

4. DNA Replication

  • Watson and Crick proposed a copying mechanism based on complementary base pairing.
  • DNA replication is semiconservative.
  • Each daughter DNA molecule has one parental strand and one newly synthesised strand.

Key Concepts

Central concept: Molecular basis of inheritance explains how DNA and RNA store, copy, transmit, and express genetic information, and how this knowledge led to ideas such as the genetic code, gene regulation, the Human Genome Project, and DNA fingerprinting.

DNA as genetic materialRNA as genetic material and functional moleculeSearch for genetic materialReplicationTranscriptionGenetic codeTranslationRegulation of gene expression

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Frequently Asked Questions

What are the important topics in Molecular Basis of Inheritance for Madhya Pradesh Board Class 12 Biology?
Key topics in Molecular Basis of Inheritance include DNA: Structure and Packaging, Search for the Genetic Material, DNA versus RNA and RNA World, DNA Replication. Study these first, then practise questions on each for the Madhya Pradesh Board Class 12 board exam.
How should I revise Molecular Basis of Inheritance for the Madhya Pradesh Board Class 12 board exam?
Learn the core ideas first, then work through the 44 practice questions on Molecular Basis of Inheritance. Revise definitions regularly and use flashcards for quick recall before the exam.

Sources & Official References

Content is aligned to the official syllabus. Refer to the board website for the latest curriculum.

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