Molecular Basis of Inheritance — Syllabus
Madhya Pradesh Board · Class 12 · Biology
What Molecular Basis of Inheritance covers in Madhya Pradesh Board Class 12 Biology: 4 topics, for the 2026-27 session.
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Topics in Molecular Basis of Inheritance
1. DNA: Structure and Packaging
- DNA is a long polymer of deoxyribonucleotides.
- A nucleotide has three parts: a nitrogenous base, a pentose sugar, and a phosphate group.
- Purines are adenine and guanine.
2. Search for the Genetic Material
- DNA was first identified as an acidic nuclear substance by Friedrich Meischer in 1869 and named Nuclein.
- Frederick Griffith worked with Streptococcus pneumoniae S and R strains in 1928.
- S strain is virulent and R strain is non-virulent.
3. DNA versus RNA and RNA World
- DNA is more stable than RNA because it lacks the 2' OH group and contains thymine.
- RNA has an extra 2' OH group, making it more reactive and less stable.
- RNA acts as genetic material in some viruses such as TMV and QB bacteriophage.
4. DNA Replication
- Watson and Crick proposed a copying mechanism based on complementary base pairing.
- DNA replication is semiconservative.
- Each daughter DNA molecule has one parental strand and one newly synthesised strand.
Key Concepts
Central concept: Molecular basis of inheritance explains how DNA and RNA store, copy, transmit, and express genetic information, and how this knowledge led to ideas such as the genetic code, gene regulation, the Human Genome Project, and DNA fingerprinting.
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