Principles of Inheritance and Variation
Tamil Nadu Board · Class 12 · Zoology
Complete topic list for Principles of Inheritance and Variation in Tamil Nadu Board Class 12 Zoology. Key concepts, sub-topics, and what to focus on for board exams.
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Topics in Principles of Inheritance and Variation
4.1 Multiple Alleles
- A gene can exist in multiple forms called alleles
- When three or more alleles of a gene occupy the same locus on homologous chromosomes, it is called multiple alleles
- Inheritance involving multiple alleles is called multiple allelism
4.2 Human Blood Groups - ABO System
- Blood group inheritance is a classic example of multiple allelism in humans
- Karl Landsteiner discovered antigens A and B on red blood cell surfaces
- Three alleles control ABO blood groups: I^A, I^B, and I^O
4.3 Genetic Control of Rh Factor
- Rh factor (Rh antigen/D antigen) discovered in 1940 in rhesus monkey blood
- Present on red blood cell surfaces like ABO antigens
- Individuals with D antigen are Rh positive (Rh⁺); those without are Rh negative (Rh⁻)
4.3.1 Erythroblastosis Foetalis (Hemolytic Disease of Newborn)
- Occurs when Rh negative mother carries Rh positive fetus
- Mother becomes sensitized during pregnancy or childbirth when fetal blood enters maternal circulation
- Maternal immune system produces anti-D antibodies (IgG type)
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