Immunobiology
Telangana Open School (TOSS) · Class 12 · Biology
Quick revision notes for Immunobiology — Telangana Open School (TOSS) Class 12 Biology. Key concepts, formulas, and definitions for last-minute revision.
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Key Topics to Revise
Concept of Self and Non-Self
- The immune system distinguishes between 'self' (the body's own cells) and 'non-self' (foreign substances like pathogens).
- Immune response is triggered only against non-self components.
- Failure to distinguish self from non-self can lead to autoimmune diseases.
Lines of Defence in the Body
- First line: Physical and chemical barriers like skin, mucus, lysozyme in tears and saliva.
- Second line: Innate immune responses including phagocytes (macrophages, neutrophils), natural killer cells, inflammation, and fever.
- Third line: Adaptive immune response involving lymphocytes (B and T cells) and antibodies.
Immune System: Organs and Cells
- Primary lymphoid organs: Bone marrow (produces all blood cells) and Thymus (matures T-cells).
- Secondary lymphoid organs: Spleen, lymph nodes, tonsils, Peyer’s patches, MALT—sites where immune responses are initiated.
- Lymphocytes are of two types: B-cells (produce antibodies) and T-cells (regulate and destroy infected cells).
Antigens and Antibodies
- Antigens are foreign molecules (usually proteins or large polysaccharides) that trigger immune response.
- Epitope is the specific part of antigen that binds to antibody; paratope is the binding site on antibody.
- Antibodies (immunoglobulins) are Y-shaped proteins produced by plasma cells derived from B-cells.
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